Dominant negative mutant Cyclin T1 proteins inhibit HIV transcription by specifically degrading Tat
<p>Abstract</p> <p>Background</p> <p>The positive transcription elongation factor b (P-TEFb) is an essential cellular co-factor for the transcription of the human immunodeficiency virus type 1 (HIV-1). The cyclin T1 (CycT1) subunit of P-TEFb associates with a viral prot...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2008-07-01
|
| Series: | Retrovirology |
| Online Access: | http://www.retrovirology.com/content/5/1/63 |