CAR T-Cell Therapy Is Effective but Not Long-Lasting in B-Cell Lymphoma of the Brain

CAR T-Cell Therapy Is Effective but Not Long-Lasting in B-Cell Lymphoma of the Brain

Advanced central nervous system (CNS) lymphoma is an exclusion criterion for most chimeric antigen receptor (CAR) T-cell studies due to the associated levels of neurotoxicity. In this study, we described five patients with chemorefractory B-cell CNS lymphoma who received CAR19 and CAR22 T-cell “Cock...

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Bibliographic Details
Main Authors: Tongjuan Li, Lei Zhao, Yuanyuan Zhang, Yi Xiao, Di Wang, Liang Huang, Liya Ma, Liting Chen, Songya Liu, Xiaolu Long, Fankai Meng, Xiaojian Zhu, Jia Wei, Bin Xu, Jianfeng Zhou, Xiaoxi Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Oncology
Subjects:
CNS lymphoma
CAR T-cell therapy
CRES
recurrence
tumor immunosuppressive microenvironment
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.01306/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2020.01306/full

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