Crystal structure of the predicted phospholipase LYPLAL1 reveals unexpected functional plasticity despite close relationship to acyl protein thioesterases

Sequence homology indicates the existence of three human cytosolic acyl protein thioesterases, including APT1 that is known to depalmitoylate H- and N-Ras. One of them is the lysophospholipase-like 1 (LYPLAL1) protein that on the one hand is predicted to be closely related to APT1 but on the other h...

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Bibliographic Details
Main Authors: Marco Bürger, Tobias J. Zimmermann, Yasumitsu Kondoh, Patricia Stege, Nobumoto Watanabe, Hiroyuki Osada, Herbert Waldmann, Ingrid R. Vetter
Format: Article
Language:English
Published: Elsevier 2012-01-01
Series:Journal of Lipid Research
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520407989