A novel interaction between CX3CR1 and CCR2 signalling in monocytes constitutes an underlying mechanism for persistent vincristine-induced pain

A novel interaction between CX3CR1 and CCR2 signalling in monocytes constitutes an underlying mechanism for persistent vincristine-induced pain

Abstract Background A dose-limiting side effect of chemotherapeutic agents such as vincristine (VCR) is neuropathic pain, which is poorly managed at present. Chemokine-mediated immune cell/neuron communication in preclinical VCR-induced pain forms an intriguing basis for the development of analgesic...

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Bibliographic Details
Main Authors: Karli Montague, Raffaele Simeoli, Joao Valente, Marzia Malcangio
Format: Article
Language:English
Published: BMC 2018-04-01
Series:Journal of Neuroinflammation
Subjects:
Vincristine
CIPN
CX3CR1
CCL2
CCR2
Monocyte
Online Access:http://link.springer.com/article/10.1186/s12974-018-1116-6

Internet

http://link.springer.com/article/10.1186/s12974-018-1116-6

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