17ß-Estradiol regulates mTORC2 sensitivity to rapamycin in adaptive cardiac remodeling.

17ß-Estradiol regulates mTORC2 sensitivity to rapamycin in adaptive cardiac remodeling.

Adaptive cardiac remodeling is characterized by enhanced signaling of mTORC2 downstream kinase Akt. In females, 17ß-estradiol (E2), as well as Akt contribute essentially to sex-related premenopausal cardioprotection. Pharmacologic mTOR targeting with rapamycin is increasingly used for various clinic...

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Bibliographic Details
Main Authors: Angelika Kusch, Maria Schmidt, Dennis Gürgen, Daniel Postpieszala, Rusan Catar, Björn Hegner, Merci M Davidson, Shokoufeh Mahmoodzadeh, Duska Dragun
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4399939?pdf=render

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http://europepmc.org/articles/PMC4399939?pdf=render

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