Honey extracts inhibit PTP1B, upregulate insulin receptor expression, and enhance glucose uptake in human HepG2 cells

Honey extracts inhibit PTP1B, upregulate insulin receptor expression, and enhance glucose uptake in human HepG2 cells

Honey is a food known for its medical properties. In this work, we have studied the impact of different types of honey on insulin signalling pathway. We found that honey extracts inhibit the enzyme PTP1B, one of the main negative regulators of insulin receptor signalling. HPLC-MS analysis allowed us...

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Bibliographic Details
Main Authors: G. Lori, L. Cecchi, N. Mulinacci, F. Melani, A. Caselli, P. Cirri, L. Pazzagli, S. Luti, L. Mazzoli, P. Paoli
Format: Article
Language:English
Published: Elsevier 2019-05-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Protein-tyrosine phosphatase 1B
Type 2 diabetes
Tuscany honey
Phenolic compounds
Insulin signaling
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332218346948

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http://www.sciencedirect.com/science/article/pii/S0753332218346948

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