miR-18a reactivates the Epstein-Barr virus through defective DNA damage response and promotes genomic instability in EBV-associated lymphomas

miR-18a reactivates the Epstein-Barr virus through defective DNA damage response and promotes genomic instability in EBV-associated lymphomas

Abstract Background The Epstein-Barr virus (EBV) is closely associated with several types of malignancies. EBV is normally present in the latent state in the peripheral blood B cell compartment. The EBV latent-to-lytic switch is required for virus spread and virus-induced carinogenesis. Immunosuppre...

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Bibliographic Details
Main Authors: Pengfei Cao, Meili Zhang, Lujuan Wang, Buqing Sai, Jiuqi Tang, Zhaohui Luo, Cijun Shuai, Liyang Zhang, Zheng Li, Yanjin Wang, Guiyuan Li, Juanjuan Xiang
Format: Article
Language:English
Published: BMC 2018-12-01
Series:BMC Cancer
Subjects:
miR-18a
EBV reactivation
DNA damage response
Genomic instability
Online Access:http://link.springer.com/article/10.1186/s12885-018-5205-9

Internet

http://link.springer.com/article/10.1186/s12885-018-5205-9

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