MicroRNAs 143 and 150 in whole blood enable detection of T-cell immunoparalysis in sepsis

MicroRNAs 143 and 150 in whole blood enable detection of T-cell immunoparalysis in sepsis

Abstract Background Currently, no suitable clinical marker for detection of septic immunosuppression is available. We aimed at identifying microRNAs that could serve as biomarkers of T-cell mediated immunoparalysis in sepsis. Methods RNA was isolated from purified T-cells or from whole blood cells o...

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Bibliographic Details
Main Authors: P Möhnle, S Hirschberger, L C Hinske, J Briegel, M Hübner, S Weis, G Dimopoulos, M Bauer, E J Giamarellos-Bourboulis, S Kreth
Format: Article
Language:English
Published: BMC 2018-10-01
Series:Molecular Medicine
Subjects:
Sepsis
Immunoparalysis
T-cells
T cell exhaustion
miRNA
Biomarker
Online Access:http://link.springer.com/article/10.1186/s10020-018-0056-z

Internet

http://link.springer.com/article/10.1186/s10020-018-0056-z

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