Heterologous Expression of Immature Forms of Human Islet Amyloid Polypeptide in Yeast Triggers Intracellular Aggregation and Cytotoxicity

Diabetes is a major public health issue that has attained alarming levels worldwide. Pancreatic aggregates of human islet amyloid polypeptide (IAPP) represent a major histopathological hallmark of type 2 diabetes. IAPP is expressed in β-cells as pre-pro-IAPP (ppIAPP) that is first processed to pro-I...

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Bibliographic Details
Main Authors: Ana F. Raimundo, Sofia Ferreira, Maria I. Farrim, Cláudia N. Santos, Regina Menezes
Format: Article
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Microbiology
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2020.02035/full