Heterologous Expression of Immature Forms of Human Islet Amyloid Polypeptide in Yeast Triggers Intracellular Aggregation and Cytotoxicity

Heterologous Expression of Immature Forms of Human Islet Amyloid Polypeptide in Yeast Triggers Intracellular Aggregation and Cytotoxicity

Diabetes is a major public health issue that has attained alarming levels worldwide. Pancreatic aggregates of human islet amyloid polypeptide (IAPP) represent a major histopathological hallmark of type 2 diabetes. IAPP is expressed in β-cells as pre-pro-IAPP (ppIAPP) that is first processed to pro-I...

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Bibliographic Details
Main Authors: Ana F. Raimundo, Sofia Ferreira, Maria I. Farrim, Cláudia N. Santos, Regina Menezes
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Microbiology
Subjects:
islet amyloid polypeptide
islet amyloid polypeptide-induced toxicity
oligomerization
protein aggregation
immature islet amyloid polypeptide
yeast model
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2020.02035/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2020.02035/full

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