PU.1 Is Required for the Developmental Progression of Multipotent Progenitors to Common Lymphoid Progenitors

PU.1 Is Required for the Developmental Progression of Multipotent Progenitors to Common Lymphoid Progenitors

The transcription factor PU.1 is required for the development of mature myeloid and lymphoid cells. Due to this essential role and the importance of PU.1 in regulating several signature markers of lymphoid progenitors, its precise function in early lymphopoiesis has been difficult to define. Here, w...

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Bibliographic Details
Main Authors: Swee Heng Milon Pang, Carolyn A. de Graaf, Douglas J. Hilton, Nicholas D. Huntington, Sebastian Carotta, Li Wu, Stephen L. Nutt
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Immunology
Subjects:
PU.1
transcription factor
multipotent progenitor
common lymphoid progenitor
Rag1
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01264/full

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https://www.frontiersin.org/article/10.3389/fimmu.2018.01264/full

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