Communication between distinct subunit interfaces of the cohesin complex promotes its topological entrapment of DNA
Cohesin mediates higher order chromosome structure. Its biological activities require topological entrapment of DNA within a lumen(s) formed by cohesin subunits. The reversible dissociation of cohesin’s Smc3p and Mcd1p subunits is postulated to form a regulated gate that allows DNA entry and exit in...
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2019-06-01
|
Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/46347 |