Communication between distinct subunit interfaces of the cohesin complex promotes its topological entrapment of DNA

Communication between distinct subunit interfaces of the cohesin complex promotes its topological entrapment of DNA

Cohesin mediates higher order chromosome structure. Its biological activities require topological entrapment of DNA within a lumen(s) formed by cohesin subunits. The reversible dissociation of cohesin’s Smc3p and Mcd1p subunits is postulated to form a regulated gate that allows DNA entry and exit in...

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Bibliographic Details
Main Authors: Vincent Guacci, Fiona Chatterjee, Brett Robison, Douglas E Koshland
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-06-01
Series:eLife
Subjects:
cohesion
cohesin
DNA binding
Smc3
Mcd1
Scc1
Online Access:https://elifesciences.org/articles/46347

Internet

https://elifesciences.org/articles/46347

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