Structural basis for pharmacological modulation of the TRPC6 channel

Structural basis for pharmacological modulation of the TRPC6 channel

Transient receptor potential canonical (TRPC) proteins form nonselective cation channels that play physiological roles in a wide variety of cells. Despite growing evidence supporting the therapeutic potential of TRPC6 inhibition in treating pathological cardiac and renal conditions, mechanistic unde...

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Bibliographic Details
Main Authors: Yonghong Bai, Xinchao Yu, Hao Chen, Daniel Horne, Ryan White, Xiaosu Wu, Paul Lee, Yan Gu, Sudipa Ghimire-Rijal, Daniel C-H Lin, Xin Huang
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-03-01
Series:eLife
Subjects:
structural biology
Cryo-EM
drug discovery
Online Access:https://elifesciences.org/articles/53311

Internet

https://elifesciences.org/articles/53311

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