Type I and III Interferon Productions Are Impaired in X-Linked Agammaglobulinemia Patients Toward Poliovirus but Not Influenza Virus

Type I and III Interferon Productions Are Impaired in X-Linked Agammaglobulinemia Patients Toward Poliovirus but Not Influenza Virus

BackgroundX-linked agammaglobulinemia (XLA) is a primary immunodeficiency caused by Bruton’s tyrosine kinase (BTK) mutation. Patients are susceptible to severe enterovirus infections. The underlying mechanism remains unknown. BTK is involved in toll-like receptors pathway, which initiates antiviral...

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Bibliographic Details
Main Authors: Anderson Dik Wai Luk, Ke Ni, Yuet Wu, Kwok-Tai Lam, Koon-Wing Chan, Pamela P. Lee, Wenwei Tu, Huawei Mao, Yu Lung Lau
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Immunology
Subjects:
type I interferon
type III interferon
X-linked agammaglobulinemia
oral poliovirus vaccine
H1N1 influenza virus
innate immunity
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01826/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01826/full

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