Optimization of mucosal responses after intramuscular immunization with integrase defective lentiviral vector.

Optimization of mucosal responses after intramuscular immunization with integrase defective lentiviral vector.

Many infectious agents infiltrate the host at the mucosal surfaces and then spread systemically. This implies that an ideal vaccine should induce protective immune responses both at systemic and mucosal sites to counteract invasive mucosal pathogens. We evaluated the in vivo systemic and mucosal ant...

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Bibliographic Details
Main Authors: Alessandra Rossi, Zuleika Michelini, Pasqualina Leone, Martina Borghi, Maria Blasi, Roberta Bona, Massimo Spada, Felicia Grasso, Alessio Gugliotta, Mary E Klotman, Andrea Cara, Donatella Negri
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4161417?pdf=render

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http://europepmc.org/articles/PMC4161417?pdf=render

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