Evodiamine inhibits insulin-stimulated mTOR-S6K activation and IRS1 serine phosphorylation in adipocytes and improves glucose tolerance in obese/diabetic mice.

Evodiamine inhibits insulin-stimulated mTOR-S6K activation and IRS1 serine phosphorylation in adipocytes and improves glucose tolerance in obese/diabetic mice.

Evodiamine, an alkaloid extracted from the dried unripe fruit of the tree Evodia rutaecarpa Bentham (Rutaceae), reduces obesity and insulin resistance in obese/diabetic mice; however, the mechanism underlying the effect of evodiamine on insulin resistance is unknown. This study investigated the effe...

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Bibliographic Details
Main Authors: Ting Wang, Tatsuya Kusudo, Tamaki Takeuchi, Yukari Yamashita, Yasuhide Kontani, Yuko Okamatsu, Masayuki Saito, Nozomu Mori, Hitoshi Yamashita
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3877036?pdf=render

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http://europepmc.org/articles/PMC3877036?pdf=render

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