Quantitative diffusion tensor imaging detects dopaminergic neuronal degeneration in a murine model of Parkinson’s disease

Quantitative diffusion tensor imaging detects dopaminergic neuronal degeneration in a murine model of Parkinson’s disease

Early diagnosis of Parkinson’s disease (PD) is required to improve therapeutic responses. Indeed, a clinical diagnosis of resting tremor, rigidity, movement and postural deficiencies usually reflect >50% loss of the nigrostriatal system in disease. In a step to address this, quantitative diffusio...

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Bibliographic Details
Main Authors: Michael D. Boska, Khader M. Hasan, Danette Kibuule, Rebecca Banerjee, Erin McIntyre, Jay A. Nelson, Theresa Hahn, Howard E. Gendelman, R. Lee Mosley
Format: Article
Language:English
Published: Elsevier 2007-06-01
Series:Neurobiology of Disease
Subjects:
Parkinson’s disease
Diffusion tensor imaging
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
MPTP
Substantia nigra
Striatum
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996107000460

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http://www.sciencedirect.com/science/article/pii/S0969996107000460

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