Critical functions for STAT5 tetramers in the maturation and survival of natural killer cells

Critical functions for STAT5 tetramers in the maturation and survival of natural killer cells

IL-15 signals through STAT5 to modulate natural killer (NK) cell maturation, function and homeostasis, but the specific contributions of STAT5 dimers and tetramers are still unclear. Here the authors show that, while STAT5 dimers are sufficient for NK development, STAT5 tetramers are essential for N...

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Bibliographic Details
Main Authors: Jian-Xin Lin, Ning Du, Peng Li, Majid Kazemian, Tesfay Gebregiorgis, Rosanne Spolski, Warren J. Leonard
Format: Article
Language:English
Published: Nature Publishing Group 2017-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-01477-5

Internet

https://doi.org/10.1038/s41467-017-01477-5

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