Positive selection in East Asians for an EDAR allele that enhances NF-kappaB activation.

Genome-wide scans for positive selection in humans provide a promising approach to establish links between genetic variants and adaptive phenotypes. From this approach, lists of hundreds of candidate genomic regions for positive selection have been assembled. These candidate regions are expected to...

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Bibliographic Details
Main Authors: Jarosław Bryk, Emilie Hardouin, Irina Pugach, David Hughes, Rainer Strotmann, Mark Stoneking, Sean Myles
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-05-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18493316/pdf/?tool=EBI