Genotype–covariate correlation and interaction disentangled by a whole-genome multivariate reaction norm model

Complex traits are often influenced by genetic and non-genetic factors (such as environmental exposures), which are themselves interconnected. Here, the authors develop a method for disentangling genotype–covariate correlation and interaction, and investigate their effects on estimating statistical...

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Bibliographic Details
Main Authors: Guiyan Ni, Julius van der Werf, Xuan Zhou, Elina Hyppönen, Naomi R. Wray, S. Hong Lee
Format: Article
Language:English
Published: Nature Publishing Group 2019-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-10128-w