Molecular basis for the disruption of Keap1–Nrf2 interaction via Hinge & Latch mechanism
Using NMR spectroscopy, Horie, Suzuki, Inoue et al. show that the dissociation of Keap1 from Nrf2, or the Hinge-Latch mechanism, is triggered by Keap1-Nrf2 inhibitors and occurs during p62- mediated Nrf2 activation, but not by electrophilic Nrf2 inducers. This study provides insights into the design...
Main Authors: | Yuta Horie, Takafumi Suzuki, Jin Inoue, Tatsuro Iso, Geoffrey Wells, Terry W. Moore, Tsunehiro Mizushima, Albena T. Dinkova-Kostova, Takuma Kasai, Takashi Kamei, Seizo Koshiba, Masayuki Yamamoto |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2021-05-01
|
Series: | Communications Biology |
Online Access: | https://doi.org/10.1038/s42003-021-02100-6 |
Similar Items
-
The Role of Sulfhydryl Reactivity of Small Molecules for the Activation of the KEAP1/NRF2 Pathway and the Heat Shock Response
by: Albena T. Dinkova-Kostova
Published: (2012-01-01) -
KEAP1, a cysteine-based sensor and a drug target for the prevention and treatment of chronic disease
by: Sharadha Dayalan Naidu, et al.
Published: (2020-06-01) -
The KEAP1–NRF2 System in Cancer
by: Keiko Taguchi, et al.
Published: (2017-05-01) -
NRF2 and the Ambiguous Consequences of Its Activation during Initiation and the Subsequent Stages of Tumourigenesis
by: Holly Robertson, et al.
Published: (2020-12-01) -
The KEAP1–NRF2 System as a Molecular Target of Cancer Treatment
by: Keiko Taguchi, et al.
Published: (2021-12-01)