Lipopolysaccharide-induced NF-κB nuclear translocation is primarily dependent on MyD88, but TNFα expression requires TRIF and MyD88

Lipopolysaccharide-induced NF-κB nuclear translocation is primarily dependent on MyD88, but TNFα expression requires TRIF and MyD88

Abstract TLR4 signalling through the MyD88 and TRIF-dependent pathways initiates translocation of the transcription factor NF-κB into the nucleus. In cell population studies using mathematical modeling and functional analyses, Cheng et al. suggested that LPS-driven activation of MyD88, in the absenc...

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Bibliographic Details
Main Authors: Jiro Sakai, Eugenia Cammarota, John A. Wright, Pietro Cicuta, Rachel A. Gottschalk, Ning Li, Iain D. C. Fraser, Clare E. Bryant
Format: Article
Language:English
Published: Nature Publishing Group 2017-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-01600-y

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https://doi.org/10.1038/s41598-017-01600-y

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