Metabolic interactions of rosmarinic acid with human cytochrome P450 monooxygenases and uridine diphosphate glucuronosyltransferases

Metabolic interactions of rosmarinic acid with human cytochrome P450 monooxygenases and uridine diphosphate glucuronosyltransferases

In light of the widespread use of herbal medicines containing rosmarinic acid (RA) and limited literature available thereon, we investigated the metabolic interactions of RA with human cytochrome P450 monooxygenases (CYPs) and uridine diphosphate glucuronosyltransferases (UGTs). The involvement of s...

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Bibliographic Details
Main Authors: Sang-Bum Kim, Kyu-Sang Kim, Dae-Duk Kim, In-Soo Yoon
Format: Article
Language:English
Published: Elsevier 2019-02-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Rosmarinic acid
Cytochrome P450 monooxygenases
Uridine diphosphate glucuronosyltransferase
Metabolism
Human liver microsomes
Human cDNA-expressed isozymes
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332218336217

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http://www.sciencedirect.com/science/article/pii/S0753332218336217

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