Hypoxia Regulates DPP4 Expression, Proteolytic Inactivation, and Shedding from Ovarian Cancer Cells

The treatment of ovarian cancer has not significantly changed in decades and it remains one of the most lethal malignancies in women. The serine protease dipeptidyl peptidase 4 (DPP4) plays key roles in metabolism and immunity, and its expression has been associated with either pro- or anti-tumour e...

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Bibliographic Details
Main Authors: Laura R Moffitt, Maree Bilandzic, Amy L Wilson, Yiqian Chen, Mark D Gorrell, Martin K Oehler, Magdalena Plebanski, Andrew N Stephens
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:International Journal of Molecular Sciences
Subjects:
MMP
Online Access:https://www.mdpi.com/1422-0067/21/21/8110