Development and Assessment of a Pooled Serum as Candidate Standard to Measure Influenza A Virus Group 1 Hemagglutinin Stalk-Reactive Antibodies

Development and Assessment of a Pooled Serum as Candidate Standard to Measure Influenza A Virus Group 1 Hemagglutinin Stalk-Reactive Antibodies

The stalk domain of the hemagglutinin has been identified as a target for induction of protective antibody responses due to its high degree of conservation among numerous influenza subtypes and strains. However, current assays to measure stalk-based immunity are not standardized. Hence, harmonizatio...

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Bibliographic Details
Main Authors: Juan Manuel Carreño, Jacqueline U. McDonald, Tara Hurst, Peter Rigsby, Eleanor Atkinson, Lethia Charles, Raffael Nachbagauer, Mohammad Amin Behzadi, Shirin Strohmeier, Lynda Coughlan, Teresa Aydillo, Boerries Brandenburg, Adolfo García-Sastre, Krisztian Kaszas, Min Z. Levine, Alessandro Manenti, Adrian B. McDermott, Emanuele Montomoli, Leacky Muchene, Sandeep R. Narpala, Ranawaka A. P. M. Perera, Nadine C. Salisch, Sophie A. Valkenburg, Fan Zhou, Othmar G. Engelhardt, Florian Krammer
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Vaccines
Subjects:
influenza vaccine
serology
hemagglutinin
stalk
standardization
Online Access:https://www.mdpi.com/2076-393X/8/4/666

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https://www.mdpi.com/2076-393X/8/4/666

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