The appearance and modulation of osteocyte marker expression during calcification of vascular smooth muscle cells.

BACKGROUND:Vascular calcification is an indicator of elevated cardiovascular risk. Vascular smooth muscle cells (VSMCs), the predominant cell type involved in medial vascular calcification, can undergo phenotypic transition to both osteoblastic and chondrocytic cells within a calcifying environment....

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Bibliographic Details
Main Authors: Dongxing Zhu, Neil Charles Wallace Mackenzie, José Luis Millán, Colin Farquharson, Vicky Elizabeth MacRae
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3096630?pdf=render