A Novel Benzofuran Derivative Moracin N Induces Autophagy and Apoptosis Through ROS Generation in Lung Cancer

A Novel Benzofuran Derivative Moracin N Induces Autophagy and Apoptosis Through ROS Generation in Lung Cancer

IntroductionThe leaves of Morus alba L is a traditional Chinese medicine widely applied in lung diseases. Moracin N (MAN), a secondary metabolite extracted form the leaves of Morus alba L, is a potent anticancer agent. But its molecular mechanism remains unveiled.ObjectiveIn this study, we aimed to...

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Bibliographic Details
Main Authors: Chengcheng Gao, Xin Sun, Zhipan Wu, Huahua Yuan, Haote Han, Hongliang Huang, Yuhan Shu, Mengting Xu, Ruilan Gao, Shouxin Li, Jianbin Zhang, Jingkui Tian
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Pharmacology
Subjects:
Moracin N
mitochondrial apoptosis
autophagy
mTOR
reactive oxygen species
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00391/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00391/full

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