MARK4 regulates NLRP3 positioning and inflammasome activation through a microtubule-dependent mechanism

MARK4 regulates NLRP3 positioning and inflammasome activation through a microtubule-dependent mechanism

Microtubules regulate activation of the NLRP3 inflammasome, but the underlying molecular mechanism is unclear. Here the authors show that MARK4 binds NLRP3 and shuttles it to the microtubule-organizing centre to promote optimal inflammasome activation.

Bibliographic Details
Main Authors: Xuan Li, Sarah Thome, Xiaodan Ma, Mamta Amrute-Nayak, Alison Finigan, Lauren Kitt, Leanne Masters, John R. James, Yuguang Shi, Guoyu Meng, Ziad Mallat
Format: Article
Language:English
Published: Nature Publishing Group 2017-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms15986

Internet

https://doi.org/10.1038/ncomms15986

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