MARK4 regulates NLRP3 positioning and inflammasome activation through a microtubule-dependent mechanism
Microtubules regulate activation of the NLRP3 inflammasome, but the underlying molecular mechanism is unclear. Here the authors show that MARK4 binds NLRP3 and shuttles it to the microtubule-organizing centre to promote optimal inflammasome activation.
Bibliographic Details
Main Authors: |
Xuan Li,
Sarah Thome,
Xiaodan Ma,
Mamta Amrute-Nayak,
Alison Finigan,
Lauren Kitt,
Leanne Masters,
John R. James,
Yuguang Shi,
Guoyu Meng,
Ziad Mallat |
Format: | Article
|
Language: | English |
Published: |
Nature Publishing Group
2017-06-01
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Series: | Nature Communications
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Online Access: | https://doi.org/10.1038/ncomms15986
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