Dysregulation of SREBP2 induces BACE1 expression

β-Amyloid hyperproduction has been observed in response to alterations in neuronal intracellular cholesterol storage, efflux, and synthesis, induced in rats by a high-fat diet. It has been suggested that cholesterol homeostasis is altered in Alzheimer's disease resulting in higher β- and γ-secr...

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Bibliographic Details
Main Authors: Raffaella Mastrocola, Michela Guglielmotto, Claudio Medana, Maria Graziella Catalano, Santina Cutrupi, Roberta Borghi, Elena Tamagno, Giuseppe Boccuzzi, Manuela Aragno
Format: Article
Language:English
Published: Elsevier 2011-10-01
Series:Neurobiology of Disease
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996111002087