Mechanical stretch-induced vascular hypertrophy occurs through modulation of leptin synthesis-mediated ROS formation and GATA-4 nuclear translocation

Mechanical stretch-induced vascular hypertrophy occurs through modulation of leptin synthesis-mediated ROS formation and GATA-4 nuclear translocation

Background: Obesity and hypertension are associated with increased leptin production contributing to cardiovascular remodeling. Mechanisms involving mechanical stretch-induced leptin production and the cross talk between signaling pathways leading to vascular remodeling have not been fully elucidate...

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Bibliographic Details
Main Authors: Crystal M Ghantous, Firas H Kobeissy, Nadia eSoudani, Farah eAbdel Rahman, Moustafa eAl Hariri, Hana A Itani, Ramzi eSabra, Asad eZeidan
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-10-01
Series:Frontiers in Pharmacology
Subjects:
Leptin
vascular smooth muscle
remodeling
ROS
Mechanical stretch
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00240/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00240/full

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