Fragile X mice have robust mGluR5-dependent alterations of social behaviour in the Automated Tube Test

Fragile X mice have robust mGluR5-dependent alterations of social behaviour in the Automated Tube Test

Fragile X syndrome is the most common monogenetic form of intellectual disability and autism. Although the Fmr1 knockout mouse model recapitulates many aspects of the human FXS condition, the establishment of robust social behavioural phenotypes suitable for drug screening has been difficult. Here,...

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Bibliographic Details
Main Authors: C.E.F. de Esch, W.E. van den Berg, R.A.M. Buijsen, I.A. Jaafar, I.M. Nieuwenhuizen-Bakker, F. Gasparini, S.A. Kushner, R. Willemsen
Format: Article
Language:English
Published: Elsevier 2015-03-01
Series:Neurobiology of Disease
Subjects:
Fragile X
Social behaviour
Tube
Glutamate receptor
ERK
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996114003921

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http://www.sciencedirect.com/science/article/pii/S0969996114003921

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