Bioenergetic bypass using cell-permeable succinate, but not methylene blue, attenuates metformin-induced lactate production

Bioenergetic bypass using cell-permeable succinate, but not methylene blue, attenuates metformin-induced lactate production

Abstract Background Metformin is the most common pharmacological treatment for type 2 diabetes. It is considered safe but has been associated with the development of lactic acidosis under circumstances where plasma concentrations exceed therapeutic levels. Metformin-induced lactic acidosis has been...

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Bibliographic Details
Main Authors: Sarah Piel, Johannes K. Ehinger, Imen Chamkha, Eleonor Åsander Frostner, Fredrik Sjövall, Eskil Elmér, Magnus J. Hansson
Format: Article
Language:English
Published: SpringerOpen 2018-08-01
Series:Intensive Care Medicine Experimental
Subjects:
Cell-permeable succinate
Human platelets
Lactic acidosis
Metformin
Methylene blue
Mitochondrial respiration
Online Access:http://link.springer.com/article/10.1186/s40635-018-0186-1

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http://link.springer.com/article/10.1186/s40635-018-0186-1

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