Bioenergetic bypass using cell-permeable succinate, but not methylene blue, attenuates metformin-induced lactate production
Abstract Background Metformin is the most common pharmacological treatment for type 2 diabetes. It is considered safe but has been associated with the development of lactic acidosis under circumstances where plasma concentrations exceed therapeutic levels. Metformin-induced lactic acidosis has been...
Main Authors: | Sarah Piel, Johannes K. Ehinger, Imen Chamkha, Eleonor Åsander Frostner, Fredrik Sjövall, Eskil Elmér, Magnus J. Hansson |
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Format: | Article |
Language: | English |
Published: |
SpringerOpen
2018-08-01
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Series: | Intensive Care Medicine Experimental |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s40635-018-0186-1 |
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