Statistical precision of the intensities retrieved from constrained fitting of overlapping peaks in high-resolution mass spectra

Least-squares fitting of overlapping peaks is often needed to separately quantify ions in high-resolution mass spectrometer data. A statistical simulation approach is used to assess the statistical precision of the retrieved peak intensities. The sensitivity of the fitted peak intensities to statist...

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Bibliographic Details
Main Authors: M. J. Cubison, J. L. Jimenez
Format: Article
Language:English
Published: Copernicus Publications 2015-06-01
Series:Atmospheric Measurement Techniques
Online Access:http://www.atmos-meas-tech.net/8/2333/2015/amt-8-2333-2015.pdf