LRRK2 inhibition prevents endolysosomal deficits seen in human Parkinson's disease

LRRK2 inhibition prevents endolysosomal deficits seen in human Parkinson's disease

LRRK2 has been implicated in endolysosomal function and likely plays a central role in idiopathic Parkinson's disease (iPD). In iPD, dopaminergic neurons within the substantia nigra are characterized by increased LRRK2 kinase activity, endolysosomal deficits, and accumulation of autophagic vesi...

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Bibliographic Details
Main Authors: Emily M. Rocha, Briana R. De Miranda, Sandra Castro, Robert Drolet, Nathan G. Hatcher, Lihang Yao, Sean M. Smith, Matthew T. Keeney, Roberto Di Maio, Julia Kofler, Teresa G. Hastings, J. Timothy Greenamyre
Format: Article
Language:English
Published: Elsevier 2020-02-01
Series:Neurobiology of Disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996119303018

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http://www.sciencedirect.com/science/article/pii/S0969996119303018

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