LRRK2 inhibition prevents endolysosomal deficits seen in human Parkinson's disease
LRRK2 has been implicated in endolysosomal function and likely plays a central role in idiopathic Parkinson's disease (iPD). In iPD, dopaminergic neurons within the substantia nigra are characterized by increased LRRK2 kinase activity, endolysosomal deficits, and accumulation of autophagic vesi...
Main Authors: | Emily M. Rocha, Briana R. De Miranda, Sandra Castro, Robert Drolet, Nathan G. Hatcher, Lihang Yao, Sean M. Smith, Matthew T. Keeney, Roberto Di Maio, Julia Kofler, Teresa G. Hastings, J. Timothy Greenamyre |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2020-02-01
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Series: | Neurobiology of Disease |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996119303018 |
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