Nonclonal Emergence of Colistin Resistance Associated with Mutations in the BasRS Two-Component System in Escherichia coli Bloodstream Isolates

Nonclonal Emergence of Colistin Resistance Associated with Mutations in the BasRS Two-Component System in Escherichia coli Bloodstream Isolates

Multidrug resistance among Gram-negative bacteria has led to the use of colistin as a last-resort drug. The cationic colistin kills Gram-negative bacteria through electrostatic interaction with the anionic lipid A moiety of lipopolysaccharides. Due to increased use in clinical and agricultural setti...

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Bibliographic Details
Main Authors: Axel B. Janssen, Toby L. Bartholomew, Natalia P. Marciszewska, Marc J. M. Bonten, Rob J. L. Willems, Jose A. Bengoechea, Willem van Schaik
Format: Article
Language:English
Published: American Society for Microbiology 2020-03-01
Series:mSphere
Subjects:
escherichia coli
antibiotic resistance
colistin
two-component regulatory systems
whole-genome sequencing
Online Access:https://doi.org/10.1128/mSphere.00143-20

Internet

https://doi.org/10.1128/mSphere.00143-20

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