Paradoxical expressions of natriuretic peptide receptor-C and neutral endopeptidase account for C-type natriuretic peptide decline during the progression of experimental obstructive nephropathy

Paradoxical expressions of natriuretic peptide receptor-C and neutral endopeptidase account for C-type natriuretic peptide decline during the progression of experimental obstructive nephropathy

Introduction: C-type natriuretic peptide (CNP) selectively binds to the guanylyl cyclase coupled natriuretic peptide receptor (NPR)-B and exerts more potent antihypertrophic and antifibrotic properties. Elimination of CNP occurs mainly by neutral endopeptidase (NEP) and NPR-C. Methods: We establishe...

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Bibliographic Details
Main Authors: Peng Hu, Xue Qi Zhao, Jing Wang, Hai Bo Kong, Bo Hu, Ling Lu, Yuan Han Qin
Format: Article
Language:English
Published: Hindawi - SAGE Publishing 2014-12-01
Series:Journal of the Renin-Angiotensin-Aldosterone System
Online Access:https://doi.org/10.1177/1470320313507121

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https://doi.org/10.1177/1470320313507121

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