Crystal Structure and Inhibitor Identifications Reveal Targeting Opportunity for the Atypical MAPK Kinase ERK3

Crystal Structure and Inhibitor Identifications Reveal Targeting Opportunity for the Atypical MAPK Kinase ERK3

Extracellular signal-regulated kinase 3 (ERK3), known also as mitogen-activated protein kinase 6 (MAPK6), is an atypical member of MAPK kinase family, which has been poorly studied. Little is known regarding its function in biological processes, yet this atypical kinase has been suggested to play im...

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Bibliographic Details
Main Authors: Martin Schröder, Panagis Filippakopoulos, Martin P. Schwalm, Carla A. Ferrer, David H. Drewry, Stefan Knapp, Apirat Chaikuad
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:International Journal of Molecular Sciences
Subjects:
atypical MAPK kinase
ERK3
MAPK6
kinase inhibitors
covalent inhibitors
Online Access:https://www.mdpi.com/1422-0067/21/21/7953

Internet

https://www.mdpi.com/1422-0067/21/21/7953

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