Neutral Sphingomyelinase-2 (NSM 2) Controls T Cell Metabolic Homeostasis and Reprogramming During Activation

Neutral Sphingomyelinase-2 (NSM 2) Controls T Cell Metabolic Homeostasis and Reprogramming During Activation

Neutral sphingomyelinase-2 (NSM2) is a member of a superfamily of enzymes responsible for conversion of sphingomyelin into phosphocholine and ceramide at the cytosolic leaflet of the plasma membrane. Upon specific ablation of NSM2, T cells proved to be hyper-responsive to CD3/CD28 co-stimulation, in...

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Bibliographic Details
Main Authors: Maria Nathalia De Lira, Sudha Janaki Raman, Almut Schulze, Sibylle Schneider-Schaulies, Elita Avota
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Molecular Biosciences
Subjects:
neutral sphingomyelinase-2
T cell receptor
Seahorse XF
oxidative phosphorylation
ATP-adenosine triphosphate
Mitochondria
Online Access:https://www.frontiersin.org/article/10.3389/fmolb.2020.00217/full

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https://www.frontiersin.org/article/10.3389/fmolb.2020.00217/full

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