UBAC1/KPC2 Regulates TLR3 Signaling in Human Keratinocytes through Functional Interaction with the CARD14/CARMA2sh-TANK Complex

UBAC1/KPC2 Regulates TLR3 Signaling in Human Keratinocytes through Functional Interaction with the CARD14/CARMA2sh-TANK Complex

CARD14/CARMA2 is a scaffold molecule whose genetic alterations are linked to human inherited inflammatory skin disorders. However, the mechanisms through which CARD14/CARMA2 controls innate immune response and chronic inflammation are not well understood. By means of a yeast two-hybrid screening, we...

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Bibliographic Details
Main Authors: Pellegrino Mazzone, Michele Congestrì, Ivan Scudiero, Immacolata Polvere, Serena Voccola, Lucrezia Zerillo, Gianluca Telesio, Pasquale Vito, Romania Stilo, Tiziana Zotti
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:International Journal of Molecular Sciences
Subjects:
CARD14
CARMA2<i>sh</i>
UBAC1
NF-κB
psoriasis
TANK
Online Access:https://www.mdpi.com/1422-0067/21/24/9365

Internet

https://www.mdpi.com/1422-0067/21/24/9365

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