Fascin1 empowers YAP mechanotransduction and promotes cholangiocarcinoma development

Fascin1 empowers YAP mechanotransduction and promotes cholangiocarcinoma development

Pocaterra et al. demonstrate that Fascin1 F-actin bundling protein sustains YAP activation in the tumour environment in response to extracellular matrix mechanical cues. This study highlights Fascin1 as a potential clinical target in intrahepatic cholangiocarcinoma development.

Bibliographic Details
Main Authors: Arianna Pocaterra, Gloria Scattolin, Patrizia Romani, Cindy Ament, Silvia Ribback, Xin Chen, Matthias Evert, Diego F. Calvisi, Sirio Dupont
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-021-02286-9

Internet

https://doi.org/10.1038/s42003-021-02286-9

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