Fitter Mitochondria Are Associated With Radioresistance in Human Head and Neck SQD9 Cancer Cells

Fitter Mitochondria Are Associated With Radioresistance in Human Head and Neck SQD9 Cancer Cells

The clinical management of head and neck squamous cell carcinoma (HNSCC) commonly involves chemoradiotherapy, but recurrences often occur that are associated with radioresistance. Using human SQD9 laryngeal squamous cell carcinoma cancer cells as a model, we aimed to identify metabolic changes assoc...

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Bibliographic Details
Main Authors: Debora Grasso, Hyllana C. D. Medeiros, Luca X. Zampieri, Vanesa Bol, Pierre Danhier, Marike W. van Gisbergen, Caroline Bouzin, Davide Brusa, Vincent Grégoire, Hubert Smeets, Alphons P. M. Stassen, Ludwig J. Dubois, Philippe Lambin, Marie Dutreix, Pierre Sonveaux
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Pharmacology
Subjects:
Head and neck cancer
radiotherapy
radioresistance mechanisms
cancer metabolism
mitochondria
oxidative phosphorylation (OXPHOS)
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00263/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00263/full

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