Variability in HIV-1 Integrase Gene and 3′-Polypurine Tract Sequences in Cameroon Clinical Isolates, and Implications for Integrase Inhibitors Efficacy

Variability in HIV-1 Integrase Gene and 3′-Polypurine Tract Sequences in Cameroon Clinical Isolates, and Implications for Integrase Inhibitors Efficacy

Integrase strand-transfer inhibitors (INSTIs) are now included in preferred first-line antiretroviral therapy (ART) for HIV-infected adults. Studies of Western clade-B HIV-1 show increased resistance to INSTIs following mutations in integrase and nef 3′polypurine tract (3′-PPT)....

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Bibliographic Details
Main Authors: Arpan Acharya, Claude T. Tagny, Dora Mbanya, Julius Y. Fonsah, Emilienne Nchindap, Léopoldine Kenmogne, Ma Jihyun, Alfred K. Njamnshi, Georgette D. Kanmogne
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:International Journal of Molecular Sciences
Subjects:
hiv
integrase inhibitors
3′polypurine tract
antiretroviral drugs
resistance-associated mutations
cameroon
Online Access:https://www.mdpi.com/1422-0067/21/5/1553

Internet

https://www.mdpi.com/1422-0067/21/5/1553

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