BDNF/TrkB axis activation promotes epithelial–mesenchymal transition in idiopathic pulmonary fibrosis

BDNF/TrkB axis activation promotes epithelial–mesenchymal transition in idiopathic pulmonary fibrosis

Abstract Background Neurotrophins (NT) belongs to a family of growth factors which promotes neurons survival and differentiation. Increasing evidence show that NT and their receptor are expressed in lung tissues suggesting a possible role in lung health and disease. Here we investigated the expressi...

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Bibliographic Details
Main Authors: Emanuela Cherubini, Salvatore Mariotta, Davide Scozzi, Rita Mancini, Giorgia Osman, Michela D’Ascanio, Pierdonato Bruno, Giuseppe Cardillo, Alberto Ricci
Format: Article
Language:English
Published: BMC 2017-09-01
Series:Journal of Translational Medicine
Subjects:
BDNF
TrkB
EMT
Idiopathic pulmonary fibrosis
Lung
Online Access:http://link.springer.com/article/10.1186/s12967-017-1298-1

Internet

http://link.springer.com/article/10.1186/s12967-017-1298-1

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