NSCs Under Strain—Unraveling the Mechanoprotective Role of Differentiating Astrocytes in a Cyclically Stretched Coculture With Differentiating Neurons

NSCs Under Strain—Unraveling the Mechanoprotective Role of Differentiating Astrocytes in a Cyclically Stretched Coculture With Differentiating Neurons

The neural stem cell (NSC) niche is a highly vascularized microenvironment that supplies stem cells with relevant biological and chemical cues. However, the NSCs’ proximity to the vasculature also means that the NSCs are subjected to permanent tissue deformation effected by the vessels’ heartbeat-in...

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Bibliographic Details
Main Authors: Jella-Andrea Abraham, Stefan Blaschke, Samar Tarazi, Georg Dreissen, Sabine U. Vay, Michael Schroeter, Gereon R. Fink, Rudolf Merkel, Maria A. Rueger, Bernd Hoffmann
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Cellular Neuroscience
Subjects:
neural stem cell
astrocyte
NSC differentiation
mechanoresponse
cyclic strain
cortical neuron
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2021.706585/full

Internet

https://www.frontiersin.org/articles/10.3389/fncel.2021.706585/full

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