SNHG5 promotes colorectal cancer cell survival by counteracting STAU1-mediated mRNA destabilization
Several lncRNAs have been linked to cancer. Here, the authors identify SNHG5 as a long non-coding RNA promoting proliferation and survival of colorectal cancer cells by protecting specific mRNAs from STAU1-mediated degradation.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2016-12-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms13875 |
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doaj-b798c3c5b5f543a9b6ab76d1380754532021-05-11T10:56:05ZengNature Publishing GroupNature Communications2041-17232016-12-017111410.1038/ncomms13875SNHG5 promotes colorectal cancer cell survival by counteracting STAU1-mediated mRNA destabilizationNkerorema Djodji Damas0Michela Marcatti1Christophe Côme2Lise Lotte Christensen3Morten Muhlig Nielsen4Roland Baumgartner5Helene Maria Gylling6Giulia Maglieri7Carsten Friis Rundsten8Stefan E. Seemann9Nicolas Rapin10Simon Thézenas11Søren Vang12Torben Ørntoft13Claus Lindbjerg Andersen14Jakob Skou Pedersen15Anders H. Lund16Biotech Research and Innovation Centre, University of CopenhagenBiotech Research and Innovation Centre, University of CopenhagenBiotech Research and Innovation Centre, University of CopenhagenDepartment for Molecular Medicine, Aarhus University HospitalDepartment for Molecular Medicine, Aarhus University HospitalBiotech Research and Innovation Centre, University of CopenhagenBiotech Research and Innovation Centre, University of CopenhagenBiotech Research and Innovation Centre, University of CopenhagenBiotech Research and Innovation Centre, University of CopenhagenCenter for Non-Coding RNA in Technology and Health, University of CopenhagenBiotech Research and Innovation Centre, University of CopenhagenBiostatistics Unit, Institut Régional du Cancer de Montpellier (ICM)—Val d’AurelleDepartment for Molecular Medicine, Aarhus University HospitalDepartment for Molecular Medicine, Aarhus University HospitalDepartment for Molecular Medicine, Aarhus University HospitalDepartment for Molecular Medicine, Aarhus University HospitalBiotech Research and Innovation Centre, University of CopenhagenSeveral lncRNAs have been linked to cancer. Here, the authors identify SNHG5 as a long non-coding RNA promoting proliferation and survival of colorectal cancer cells by protecting specific mRNAs from STAU1-mediated degradation.https://doi.org/10.1038/ncomms13875 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Nkerorema Djodji Damas Michela Marcatti Christophe Côme Lise Lotte Christensen Morten Muhlig Nielsen Roland Baumgartner Helene Maria Gylling Giulia Maglieri Carsten Friis Rundsten Stefan E. Seemann Nicolas Rapin Simon Thézenas Søren Vang Torben Ørntoft Claus Lindbjerg Andersen Jakob Skou Pedersen Anders H. Lund |
| spellingShingle |
Nkerorema Djodji Damas Michela Marcatti Christophe Côme Lise Lotte Christensen Morten Muhlig Nielsen Roland Baumgartner Helene Maria Gylling Giulia Maglieri Carsten Friis Rundsten Stefan E. Seemann Nicolas Rapin Simon Thézenas Søren Vang Torben Ørntoft Claus Lindbjerg Andersen Jakob Skou Pedersen Anders H. Lund SNHG5 promotes colorectal cancer cell survival by counteracting STAU1-mediated mRNA destabilization Nature Communications |
| author_facet |
Nkerorema Djodji Damas Michela Marcatti Christophe Côme Lise Lotte Christensen Morten Muhlig Nielsen Roland Baumgartner Helene Maria Gylling Giulia Maglieri Carsten Friis Rundsten Stefan E. Seemann Nicolas Rapin Simon Thézenas Søren Vang Torben Ørntoft Claus Lindbjerg Andersen Jakob Skou Pedersen Anders H. Lund |
| author_sort |
Nkerorema Djodji Damas |
| title |
SNHG5 promotes colorectal cancer cell survival by counteracting STAU1-mediated mRNA destabilization |
| title_short |
SNHG5 promotes colorectal cancer cell survival by counteracting STAU1-mediated mRNA destabilization |
| title_full |
SNHG5 promotes colorectal cancer cell survival by counteracting STAU1-mediated mRNA destabilization |
| title_fullStr |
SNHG5 promotes colorectal cancer cell survival by counteracting STAU1-mediated mRNA destabilization |
| title_full_unstemmed |
SNHG5 promotes colorectal cancer cell survival by counteracting STAU1-mediated mRNA destabilization |
| title_sort |
snhg5 promotes colorectal cancer cell survival by counteracting stau1-mediated mrna destabilization |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2016-12-01 |
| description |
Several lncRNAs have been linked to cancer. Here, the authors identify SNHG5 as a long non-coding RNA promoting proliferation and survival of colorectal cancer cells by protecting specific mRNAs from STAU1-mediated degradation. |
| url |
https://doi.org/10.1038/ncomms13875 |
| work_keys_str_mv |
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1721447325870587904 |