Scavenging Intracellular ROS Attenuates <i>p</i>-Cresyl Sulfate-Triggered Osteogenesis Through MAPK Signaling Pathway and NF-κB Activation in Human Arterial Smooth Muscle Cells

Scavenging Intracellular ROS Attenuates <i>p</i>-Cresyl Sulfate-Triggered Osteogenesis Through MAPK Signaling Pathway and NF-κB Activation in Human Arterial Smooth Muscle Cells

Osteogenesis in human arterial smooth muscle cell (HASMC) is a key feature of uremic vascular calcification (UVC). Concerning pro-oxidant properties of <i>p</i>-cresyl sulfate (PCS), the therapeutic effect of reactive oxygen species (ROS) scavenger on PCS triggered inflammatory signaling...

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Bibliographic Details
Main Authors: Jia-Feng Chang, Chih-Yu Hsieh, Jian-Chiun Liou, Shih-Hao Liu, Chi-Feng Hung, Kuo-Cheng Lu, Chih-Cheng Lin, Chang-Chin Wu, Shuk-Man Ka, Li-Li Wen, Mai-Szu Wu, Cai-Mei Zheng, Wen-Chin Ko
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Toxins
Subjects:
alkaline phosphatase
c-Jun N-terminal kinase
extracellular signal-regulated kinase
mitogen-activated protein kinase
nuclear factor-κB
osteogenesis
Online Access:https://www.mdpi.com/2072-6651/12/8/472

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https://www.mdpi.com/2072-6651/12/8/472

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