Self-nanoemulsifying system improves oral absorption and enhances anti-acute myeloid leukemia activity of berberine

Self-nanoemulsifying system improves oral absorption and enhances anti-acute myeloid leukemia activity of berberine

Abstract Background Recently, we found that berberine (BBR) exerts anti-acute myeloid leukemia activity, particularly toward high-risk and relapsed/refractory acute myeloid leukemia MV4-11 cells in vitro. However, the poor water solubility and low bioavailability observed with oral BBR administratio...

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Bibliographic Details
Main Authors: Jieping Li, Li Yang, Rui Shen, Li Gong, Zhiqiang Tian, Huarong Qiu, Zhe Shi, Lichen Gao, Hongwu Sun, Guangsen Zhang
Format: Article
Language:English
Published: BMC 2018-10-01
Series:Journal of Nanobiotechnology
Subjects:
Berberine
Self-nanoemulsifying system
Acute myeloid leukemia
MV4-11
Caco-2 monolayer transport
Online Access:http://link.springer.com/article/10.1186/s12951-018-0402-x

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http://link.springer.com/article/10.1186/s12951-018-0402-x

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