Ligustilide Attenuates Ischemia Reperfusion-Induced Hippocampal Neuronal Apoptosis via Activating the PI3K/Akt Pathway

Ligustilide Attenuates Ischemia Reperfusion-Induced Hippocampal Neuronal Apoptosis via Activating the PI3K/Akt Pathway

Ligustilide (LIG), a main lipophilic component isolated from Cnidii Rhizoma (Cnidium officinale, rhizome) and Angelicae Gigantis Radix (Angelica gigas Nakai, root), has been shown to alleviate cerebral ischemia injury and paly a neuroprotective role. We investigated mechanisms underlying the antiapo...

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Bibliographic Details
Main Authors: Qian Wu, Zhiguo Mao, Jiao Liu, Jinling Huang, Ning Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Pharmacology
Subjects:
ligustilide
oxygen-glucose deprivation/reperfusion
hippocampal neurons
apoptosis
PI3K/Akt
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00979/full

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https://www.frontiersin.org/article/10.3389/fphar.2020.00979/full

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